Gidazepam

Gidazepam
Chemische structuur
Farmaceutische gegevens
Halveringstijd (t1/2)	~87 uur
Uitscheiding	renaal
Gebruik
Toediening	Oraal
Databanken
CAS-nummer	129186-29-4
PubChem	121919
Chemische gegevens
Molecuulformule
IUPAC-naam	2-(9-Bromo-3-oxo-6-phenyl- 2,5-diazabicyclo[5.4.0] undeca-5,8,10,12-tetraen-2-yl) acetohydrazide
SMILES	BrC1=CC2=C(C=C1)N(CC(NN)=O) C(CN=C2C3=CC=CC=C3)=O
Portaal	Geneeskunde

Gidazepam, ook bekend als hydazepam of hidazepam,^[1] is een medicijn dat een atypisch benzodiazepinederivaat is, ontwikkeld in de Sovjet-Unie.^[2]^[3] Het is een selectief anxiolytisch benzodiazepine.^[4] Het heeft ook therapeutische waarde bij de behandeling van bepaalde cardiovasculaire aandoeningen.^[5]^[6]^[7]^[8]^[9] Gidazepam is niet geregistreerd voor gebruik door het Europees Geneesmiddelenbureau of de Amerikaanse Food and Drug Administration.

Gidazepam is een prodrug voor zijn actieve metaboliet (desalkyl-gidazepam of broom-nordazepam).^[10]^[11] Het wordt gebruikt als een medicijn tegen angst. Het kan echter enkele uren duren voordat de anxiolytische effecten zich na toediening manifesteren, aangezien het de actieve metaboliet is die voornamelijk de anxiolytische effecten veroorzaakt, en de halfwaardetijd van gidazepam tot de langste van alle benzodiazepinen behoort.^[12]

De actieve metaboliet **desalkyl-gidazepam**, verantwoordelijk voor de therapeutische effecten ervan

Bronnen, noten en/of referenties

↑ Library of Congress (2006). Library of Congress Subject Headings. Library of Congress, 3300–.
↑ (september 1991). [The new Soviet tranquilizer--gidazepam]. Fel'dsher I Akusherka 56 (9): 35–7. PMID 1684941.
↑ (maart 2002). [Experimental and clinical rationale for complex treatment of mental disorders in clean-up workers of the Chernobyl nuclear plant accident]. Eksperimental'naia i Klinicheskaia Farmakologiia 65 (2): 12–6. PMID 12109283.
↑ (februari 2002). Affinities of gidazepam and its analogs for mitochondrial benzodiazepine receptors. Journal of Receptor and Signal Transduction Research 22 (1–4): 411–20. PMID 12503630. DOI: 10.1081/RRS-120014610.
↑ (januari 1998). [The effect of gidazepam on the cardiovascular system function in patients with neurotic reactions and in healthy subjects under aggravated conditions]. Eksperimental'naia i Klinicheskaia Farmakologiia 61 (1): 30–2. PMID 9575408.
↑ (1994). [The neuroregulatory modulation of the hemodynamic reactions to physical loading in patients with cardiac arrhythmias]. Terapevticheskii Arkhiv 66 (9): 65–8. PMID 7992218.
↑ (september 1993). [New pharmacodynamic effects of gidazepam and befol in patients with cardiac arrhythmias]. Eksperimental'naia i Klinicheskaia Farmakologiia 56 (5): 23–7. PMID 7906171.
↑ (juni 1992). [Comparative analysis of antiarrhythmic action and electrophysiological effects of a new benzodiazepine derivative gidazepam and ethacizin in arrhythmias of various genesis]. Kardiologiia 32 (6): 35–7. PMID 1405290.
↑ (april 1992). [Comparative anti-arrhythmia effectiveness of activators of body stress-limiting systems in patients with arrhythmia]. Kardiologiia 32 (4): 25–30. PMID 1328745.
↑ (januari 1992). [Biokinetics of a new prodrug gidazepam and its metabolite]. Biulleten' Eksperimental'noi Biologii I Meditsiny 113 (1): 45–7. PMID 1356504.
↑ (mei 1993). [Gidazepam biotransformation and pharmacokinetics in different species of animals and man]. Eksperimental'naia i Klinicheskaia Farmakologiia 56 (3): 48–50. PMID 8106054.
↑ (mei 1993). [The pharmacokinetic aspects of the clinical action of gidazepam]. Eksperimental'naia i Klinicheskaia Farmakologiia 56 (3): 50–2. PMID 8106055.

[Congress2006-1] Library of Congress (2006). Library of Congress Subject Headings. Library of Congress, 3300–.

[2] (september 1991). [The new Soviet tranquilizer--gidazepam]. Fel'dsher I Akusherka 56 (9): 35–7. PMID 1684941.

[3] (maart 2002). [Experimental and clinical rationale for complex treatment of mental disorders in clean-up workers of the Chernobyl nuclear plant accident]. Eksperimental'naia i Klinicheskaia Farmakologiia 65 (2): 12–6. PMID 12109283.

[4] (februari 2002). Affinities of gidazepam and its analogs for mitochondrial benzodiazepine receptors. Journal of Receptor and Signal Transduction Research 22 (1–4): 411–20. PMID 12503630. DOI: 10.1081/RRS-120014610.

[5] (januari 1998). [The effect of gidazepam on the cardiovascular system function in patients with neurotic reactions and in healthy subjects under aggravated conditions]. Eksperimental'naia i Klinicheskaia Farmakologiia 61 (1): 30–2. PMID 9575408.

[6] (1994). [The neuroregulatory modulation of the hemodynamic reactions to physical loading in patients with cardiac arrhythmias]. Terapevticheskii Arkhiv 66 (9): 65–8. PMID 7992218.

[7] (september 1993). [New pharmacodynamic effects of gidazepam and befol in patients with cardiac arrhythmias]. Eksperimental'naia i Klinicheskaia Farmakologiia 56 (5): 23–7. PMID 7906171.

[8] (juni 1992). [Comparative analysis of antiarrhythmic action and electrophysiological effects of a new benzodiazepine derivative gidazepam and ethacizin in arrhythmias of various genesis]. Kardiologiia 32 (6): 35–7. PMID 1405290.

[9] (april 1992). [Comparative anti-arrhythmia effectiveness of activators of body stress-limiting systems in patients with arrhythmia]. Kardiologiia 32 (4): 25–30. PMID 1328745.

[10] (januari 1992). [Biokinetics of a new prodrug gidazepam and its metabolite]. Biulleten' Eksperimental'noi Biologii I Meditsiny 113 (1): 45–7. PMID 1356504.

[11] (mei 1993). [Gidazepam biotransformation and pharmacokinetics in different species of animals and man]. Eksperimental'naia i Klinicheskaia Farmakologiia 56 (3): 48–50. PMID 8106054.

[12] (mei 1993). [The pharmacokinetic aspects of the clinical action of gidazepam]. Eksperimental'naia i Klinicheskaia Farmakologiia 56 (3): 50–2. PMID 8106055.

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