Stikstofmosterd: verschil tussen versies

== Reactiemechanisme ==

{{Zie hoofdartikel|Mosterdgas#Werkingsmechanisme|Mosterdgas}}

 

In de vroege jaren zestig van de 20e&nbsp;eeuw werd vastgesteld dat stikstofmosterds koppelingen tussen de DNA-strengen aanbrachten.<ref>Geiduschek EP: "Reversible" DNA. Proc Natl Acad Sci U S A 1961, 47:950-955.</ref><ref>Brookes P, Lawley PD: The reaction of mono- and di-functional alkylating agents with nucleic acids. Biochem J 1961, 80(3): pp. 496-503</ref><ref>Rink SM, Solomon MS, Taylor MJ, Rajur SB, McLaughlin LW, Hopkins PB: Covalent structure of a nitrogen mustard-induced DNA interstrand cross-link: An N7-to-N7 linkage of deoxyguanosine residues at the duplex sequence 5'-d(GNC). Journal of the American Chemical Society 1993, vol. 115, pp. 2551-2557</ref><ref>Dong Q, Barskt D, Colvin ME, Melius CF, Ludeman SM, Moravek JF, Colvin OM, Bigner DD, Modrich P, Friedman HS: A structural basis for a phosphoramide mustard-induced DNA interstrand cross-link at 5?-d(GAC). Proceedings of the National Academy of Sciences of the United States of America 1995, 92(26): pp. 12170-12174</ref><ref>Bauer GB, Povirk LF: Specificity and kinetics of interstrand and intrastrand bifunctional alkylation by nitrogen mustards at a G-G-C sequence. Nucleic Acids Res 1997, volume 25, pp. 1211-1218</ref>